Toleransen for høye doser kan avta raskt dersom man slutter med opioider eller har en pause i bruk. I slike tilfeller er male spesielt utsatt for overdoser dersom person inntar samme dose som tidligere.Behandling i spesialisthelsetjenesten krever henvisning fra lege for eksempel fastlege / allmennpraktiserende lege, privatpraktiserende legespesial

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